About Acute Decompensated Heart Failure


Approximately 1.8 million patients are admitted with ADHF in the Unites States annually.1

#1 Cause

Acute Decompensated Heart failure (ADHF) is the leading cause of hospitalization in patients older than 65 years of age.2

30% Mortality

Mortality after ADHF hospitalization approaches 30% annually and readmission is common, despite treatment with currently available pharmacotherapy and device therapy for HF.1,3

Congestion Is Critical Therapy Target

Most hospitalized patients have significant volume overload, and congestive symptoms predominate.4


Overall annual cost and $20B hospitalization cost, 43% of MediCare part A and Part B spending.5

Unmet Need

While current approaches may alleviate some symptoms, many patients continue to worsen, thus the need for development of new therapies to focus on the critical time during hospitalization.

1. Am. Journal of Epidemiology, February 19,2016; 183(5): 462-470. Temporal Trends in Hospitalizations for ADHF in the US, 1998-2011 2. Am Heart J.  2003;  145:S18-S25. The Problem of Decompensated Heart Failure:  nomenclature, classification and risk stratification.3. Circulation Heart Failure 2010; 3(1): 97-103.  Recent National Trends in Readmission Rates after Heart Failure Hospitalization. 4. J Card Fail. 2016; 22(3): 182-189.  Hemodynamic Predictors of Heart Failure Morbidity and Mortality:  Fluid or Flow? 5. Linden A, Adler-Milstein J. Medicare disease management in policy context. Health Care Financ Rev. 2008;29(3):1-11